Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with bushranger awning short life expectancy and no effective therapy.We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cell activation.When anti-miR-124-tr